Anaplastic lymphoma kinase (ALK, anaplastic lymphoma kinase) is a receptor type tyrosine kinase, and is found to be expressed in the central and peripheral nervous system at late embryonic stage. Motegi et al. developed an agonist monoclonal antibody against the extracellular domain of ALK. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. And it also induces further phosphorylation of signal transfer molecules like IRD-1 (insulin receptor substrate-1) which interact with ALK. Moreover, continuous incubation with this antibody induced the cell-growth and neurite outgrowth of SK-N-SH cells. For research use only, not for use in diagnostic procedures.
- application:
- WB, IP
- Catalog number:
- 10373
- clone:
- mAb 16-39
- concentration:
- Please see datasheet
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Recombinant protein of the extracellular domain of mouse ALK
- isotype:
- IgG2b
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- size:
- 100 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
- Species:
- Mouse
- Host:
- Rat
