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Alpha Klotho ELISA Kits

Alpha Klotho (α-Klotho) is a key player that integrates a multi-step regulatory system of calcium metabolism and phosphate homeostasis.

Alpha Klotho (α-Klotho) was identified as an extremely down-regulated gene in the genetic mutation mouse (Klotho mouse) of which phenotype is very similar to various symptoms of human aging. Then, the sequences of Alpha Klotho (α-Klotho) genes have been identified in various species including human based on the one of mouse. α-Klotho protein is a 130kDa, one-transmembrane protein and its expression is confirmed in the kidneys and the parathyroid glands.

In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus. Therefore, it is considered that, in Klotho mouse, early aging-like symptoms are induced by impaired mineral homeostasis caused by decreased expression of α- Klotho.

Meanwhile, it is reported that the long N-terminal extracellular domain which comprises the major portion of sequence of α-Klotho protein is released free into blood by shedding. However, there are may unclear points about functions and changes in concentration of free (soluble) α-Klotho protein, so it has been required to develop the measurement system of α-Klotho.

We offer a solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma and a solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine.

For research use only, not for use in diagnostic procedures.

  • FGF23 (Human Intact FGF23) CLEIA ELISA

    FGF23 (Human Intact FGF23) CLEIA ELISA

    FGF23 (Fibroblast Growth Factor 23) is a protein belonging to the fibroblast growth factor family. FGF23 is involved in the regulation of phosphorus metabolism. FGF23 has a molecular weight of approximately 32 kDa. FGF23 is produced in bone cells. In...

    $1,341.00
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  • Human secreted Alpha Klotho (α-Klotho) ELISA

    Human secreted Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of human secreted Alpha Klotho ( α-Klotho ) in serum, EDTA-plasma, and cerebrospinal fluids (CSF). For research use only, not for use in diagnostic procedures.<br><br> α-Klotho...

    $827.00
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  • Human soluble Alpha Klotho (α-Klotho) ELISA

    Human soluble Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma. For research use only, not for use in diagnostic procedures.<br><br> α-Klotho is a key player that integrates a...

    $827.00
    Add to Cart
  • Mouse soluble Alpha Klotho (α-Klotho) ELISA

    Mouse soluble Alpha Klotho (α-Klotho) ELISA

    Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. <br><br> α-klotho (Alpha Klotho) was identified as an...

    $827.00
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