Amyloid Beta (1-40) (Mouse/Rat) Aβ

Solid phase sandwich ELISA for the determination of Mouse/Rat Aβ ( 1-40 ) in mouse/rat brain extract, plasma, serum, and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br>

The first case of Alzheimer's disease was defined and reported in 1907 by the German scientist, Dr. A. Alzheimer. His studies have shown that this is the main cause of dementia in the elderly. The plaques which appear in the brains of Alzheimer's disease patients are mostly constituted by the Amyloid Beta (Amyloidβ, Aβ) protein. Aβ is a peptide which consists of 40 or 42 (43) amino acids, and reports show that this is cleaved from β- and γ- secretase from the amyloid precursor protein. APP is a trans-membrane protein consisting of 695, 751, or 770 amino acids. Reports have shown many variants of Aβ exist and are clarified into the culture supernatant from the APP cDNA transfected mouse neuroblastoma cell. Furthermore, in 1995, a dominant and differential deposition of distinct βamyloid peptide species, Aβ (N3pE), in senile plaques was found by Saido et al. This modified molecule, starting at the 3rd amino terminal residue, glutamate, was discovered to convert to pyroglutamate through intramolecular dehydration. The IBL Code No. 27713 can be measured Aβ (1-40) variants cleaved N terminal side by any cause. The IBL Code No. 27714, Human Amyloidβ (1-40) (N) Assay Kit and IBL Code No. 27718 Human Amyloidβ (1-40) (FL) Assay Kit are separately prepared when you want to measure Aβ (1-40) which held N terminal side completely. In addition, Human Amyloidβ (1-40) (N) Assay Kit uses a polyclonal antibody as Labeled antibody. On the other hand, the Human Amyloidβ (1-40) (FL) Assay Kit uses a monoclonal antibody. Moreover, in assay of Aβ (1-42) variants cleaved N terminal side, it is a Human Amyloidβ (1-42) Assay Kit similarly. When measuring Aβ (1-42) variants cleaved by N terminal side, please use IBL Code No.27711, Human Amyloidβ (1-42) Assay Kit. And, when measuring Aβ (1-42) which held N terminal side completely, please use IBL Code No.27712, Human Amyloidβ(1-42) (N) Assay Kit. Furthermore, in measurement of Aβ (N3pE-42), please use IBL Code No.27716. Human Amyloidβ (N3pE) assay Kit. Thus, it will be very useful for Alzheimer's research to assay Aβ (1-40), Aβ (1-42), and Aβ (N3pE-42), respectively.