Amyloid Beta (82E1-specific) Aβ Oligomers

Alzheimer's disease (AD) is a neurodegenerative disease which Amyloid beta (Aβ) peptide accumulates in a brain and the predominant symptom is a decline of cognitive functions. It has been generally thought that Aβ which condenses and become insoluble fiber (fibril) forms the senile plaque and this denatures neurons and develops the symptoms of the disease. (This is called the 'amyloid hypothesis'.) However, 'oligomer hypothesis' is becoming potent these days that the disease is developed by decline in cognitive function because of the soluble Aβ oligomer which is a middle object of a condensation process has strong synaptic injurious effects. It is reported that when the Aβ oligomer which is secreted from the cell or is extracted from the brain of individuals who suffer AD is injected into rat brain, it causes synaptic dysfunction and study memory loss. Moreover, it is also actually observed that the Aβ oligomers are increasing in brains of individuals who suffer AD compared with healthy individuals. IBL has many other kinds of Amyloidβ-related products for AD research. They are very specific assay systems for each target and they can be used according to the purpose of study.<br><br>

Keywords:
Alzheimer's Disease / Amyloid β / Amyloid-β/ Amyloid Beta / Beta Amyloid / Aβ / Oligomers / Toxic Oligomers