Amyloid Beta / APP Kits & Antibodies

Alzheimer's disease is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NTFs) in the brain.

Amyloid Beta is a peptide derived from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ is the main component of Amyloid plaques, which are insoluble clumps of beta proteins that are potentially toxic to neurons and their synapses.

Research suggests that the plaques disrupt communication between brain cells, which would result in cognitive decline.

The Tau protein is a microtubule-associated protein which stabilizes the microtubules that transport intracellular substances in nerve cells. When Tau malfunctions, it detaches from these microtubules and sticks to other Tau molecules, where threads are formed. These threads eventually result in neurofibrillary tangle.

Since Tau is interfering with intraneuronal transport and metabolism during this process, research suggests this plays another major role in cognitive decline.

In addition to a complete selection of research assays for the various Amyloid beta molecules, IBL-America also offers antibodies and test kits targeting Tau protein, APPα and β, as well as other significant molecules.

Amyloid Precursor Protein 770 (APP770)

Solid phase sandwich ELISA for the determination human APP770 in EDTA-plasma, cerebrospinal fluid and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer's disease (AD) is a typical senile...

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Amyloid β Toxic Oligomer

Solid phase sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of Amyloid β Toxic Oligomer in cerebrospinal fluids. For research use only, not for use in diagnostic procedures. Oligomerization of Amyloidβ (Amyloid Beta)...

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Anti-APP (18) Rabbit IgG Affinity Purify

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...

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Anti-APP (Phosphorylated) Rabbit IgG Affinity Purify

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...

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APP (597) Anti-Mouse/Rat Rabbit IgG Affinity Purify

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...

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APP (C) Anti-Human Rabbit IgG Affinity Purify

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...

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APP (N) (10D1) Anti-Human Mouse IgG MoAb

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...

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APP βCTF

Solid phase sandwich ELISA for the determination of Human APP βCTF in cell lysate. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer’s disease (AD) was first reported by A. Alzheimer, a German...

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APP770 (351) Anti-Human Rabbit IgG Affinity Purify

Alzheimer's disease (AD) is a typical senile dementia and it is believed that accumulation of Amyloidβ (Aβ) in brain parenchyma is a major cause of the disease. Meanwhile, accumulation of Aβ has been also observed on cerebrovascular walls...

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Human NfL (Neurofilament light chain) ELISA

Neurofilaments are intermediate diameter (10nm) filaments that are located in neurons specifically. They are usually composed of three mid-diameter filament proteins, NfL, NfM, and NfH, and are associated with the maintenance of the inner diameter of...

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Human Phopsho Tau (217P) ELISA

Tau protein is a microtubule-associated protein of 45-50 kDa consisting of 352-441 amino acids. It plays a role in stabilizing microtubules that transport intracellular substances in neurons. Tauopathies such as Alzheimer's disease (AD) and...

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Human Phospho Tau (181P) ELISA

Tau protein is a 45-50kDa microtubule-associated protein which consists of 352-441 amino acids. It has a role of stabilizing microtubules that transport intracellular substances in nerve cells. It is known that tauopathy such as Alzheimer's type dementia...

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