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Human sAPPα (highly sensitive)
Solid phase sandwich ELISA for the determination of human sAPPα in serum, EDTA plasma, cerebrospinal fluids and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer's disease (AD) was...
Add to Cart$654.00 -
Human secreted Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of human secreted Alpha Klotho ( α-Klotho ) in serum, EDTA-plasma, and cerebrospinal fluids (CSF). For research use only, not for use in diagnostic procedures.<br><br> α-Klotho...
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Human soluble Alpha Klotho (α-Klotho) Control Set
Used as a complementary component for Human soluble Alpha Klotho (α-Klotho), catalog #27998. For research use only, not for use in diagnostic procedures.
Add to Cart$136.00 -
Human Total Tau ELISA
Tau protein is a 45-50kDa microtubule-associated protein which consists of 352-441 amino acids. It has a role of stabilizing microtubules that transport intracellular substances in nerve cells. It is known that tauopathy such as Alzheimer's type dementia...
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Mouse soluble Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. <br><br> α-klotho (Alpha Klotho) was identified as an...
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sAPP Total (Highly Sensitive)
Solid phase sandwich ELISA for the determination of human total sAPP in serum, EDTA plasma, cerebrospinal fluid and cell culture supernatant as a total amount. For research use only, not for use in diagnostic procedures...
Add to Cart$654.00 -
sAPPα (2B3) Anti-Human Mouse IgG MoAb
Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative...
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sAPPα (Mouse/Rat) (highly sensitive)
Solid phase sandwich ELISA for the determination Mouse/Rat sAPPα in serum, EDTA plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures. <br><br> Alzheimer’s disease (AD) was first...
Add to Cart$830.00 -
sAPPβ-sw (6A1) Anti-Human Mouse IgG MoAb
Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by betaand gamma-secretases. A double missense mutation (Lys670→Asn and Met671→Leu) in APP found in a Swedish pedigree (APPβ-sw) elevates Abeta40 and...
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sAPPβ-sw (highly sensitive)
Solid phase sandwich ELISA for the determination of Human sAPPβ-sw in EDTA-plasma of the Tg2576 transgenic mouse and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer's disease...
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sAPPβ-w (Highly Sensitive)
Solid phase sandwich ELISA for the determination human sAPPβ-w in EDTA plasma, cerebrospinal fluids and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer's disease (AD) was first...
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sAPPβ-w (Mouse)
Solid phase sandwich ELISA for the determination of sAPPβ-w in mouse plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br> Alzheimer's disease (AD) was first reported by A. Alzheimer,...
Add to Cart$852.00
Amyloid Beta / APP Kits & Antibodies
Alzheimer's disease is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NTFs) in the brain.
Amyloid Beta is a peptide derived from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ is the main component of Amyloid plaques, which are insoluble clumps of beta proteins that are potentially toxic to neurons and their synapses.
Research suggests that the plaques disrupt communication between brain cells, which would result in cognitive decline.
The Tau protein is a microtubule-associated protein which stabilizes the microtubules that transport intracellular substances in nerve cells. When Tau malfunctions, it detaches from these microtubules and sticks to other Tau molecules, where threads are formed. These threads eventually result in neurofibrillary tangle.
Since Tau is interfering with intraneuronal transport and metabolism during this process, research suggests this plays another major role in cognitive decline.
In addition to a complete selection of research assays for the various Amyloid beta molecules, IBL-America also offers antibodies and test kits targeting Tau protein, APPα and β, as well as other significant molecules.