ANGPTL8

Angiopoietin-like protein 8 (ANGPTL 8) is a protein consisting of 198 amino acids that is secreted mainly from the liver and fatty tissue. It is also known as Betatrophin, Lipasin, refeeding induced fat and liver (RIFL) and TD 26. It is classified as an atypical member of the ANGPTL family as ANGPTL8 is highly homologous with the N-terminal domain of ANGPTL3 and ANGPTL4. It does not have a C-terminal fibrinogen-like domain which is common to the ANGPTL family. It has been shown that triglyceride levels become lower in plasma samples of ANGPTL8 deficient mice compared to the levels in wild-type mice after feeding. Reports show that triglyceride levels in plasma samples is elevated only if ANGPTL8 is overexpressed in presence of ANGPTL3. It is considered that ANGPTL8 becomes a targeted molecule for improving current drugs for hyperlipidemia or as a biomarker of metabolic diseases (Reference 1) as ANGPTL8 is a lipoprotein regulatory factor that inhibits LPL activity through activation of ANGPTL3. This ELISA kit can measure the full length of ANGPTL8 in human samples. Solid phase sandwich ELISA for the determination of Human ANGPTL8 ELISA in serum, EDTA plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures.