Anti-Dock8 Rabbit IgG Affinity Purify 1

Small GTPase of Rho family is one of signaling factors which control alteration of cellular morphology, cell division and differentiation, and plays an important role in regulation of generation and organogenesis at an individual level. Its functions are strictly regulated and its dysfunction causes many diseases such as immunological disease or neurodegenerative disease. Dedicator of cytokinesis (Dock) 8 is a Rho family small GTPase activating factor (or exchange factor) activating Rac1 and Cdc42 specifically of the Rho family small GTPase. It is considered that Dock8 is an important factor for proliferation and differentiation of immnocytes, neurocytes and stem cells since it is more expressed especially in immune system, nerve tissues and tissues of fetal stage. It is known as a responsible gene for hyper-IgE syndrome, and many types of genetic mutations have been reported. Additionally, relation with blood tumors has been pointed out. There are proteins, called Dock6 and Dock7, very similar to Dock8 in human but there are still many unclear points about their regulation systems. For research use only, not for use in diagnostic procedures.