Girdin is a new protein playing an important role in the infiltration and metastasis of cancer cells. A new substance of Akt, Girdin (Girders of actin filament) was discovered by a research group led by Takahashi et al., Nagoya University by screening using yeast two-hybrid method and was elucidated that Girdin has an important role for cell migration downstream of Akt. <br><br>
It has been proven that Girdin is a new actin binding protein and it restructures actin fibers upon it is phosphorylated by Akt and it involves in forming of lamellipodia that is located at the leading edge of cells and playing an important roles for cell migration by functional analysis. Various antibodies inclusive phosphorylated Girdin antibodies are provided by IBL and it has been suggested that the change of condition of phosphorylated Girdin involves in structure alteration in relation to cell migration in vivo or in vitro by current studies used these antibodies. For research use only, not for use in diagnostic procedures.
- application:
- WB, ICC
- Catalog number:
- 28145
- Datasheet:
- formulation:
- Lyophilized product in PBS containing 1% BSA and 0.05% NaN3
- immunogen:
- Synthetic peptide of the phosphorylated part of Human Girdin (RKTEDT(pY)FISSAG)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Protocol:
- purification:
- Affinity purified with antigen peptide
- size:
- 50 µg
- specificity:
- Cross-react with Human Phosphorylated Girdin
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- species:
- Human
- host:
- Rabbit
- Additional info:
