Small-G-protein Rab is a regulator of membrane transport, and is highly conserved and ubiquitously expressed in all eukaryotes. More than 60 Rab isoforms have been reported in humans, and they are thought to be involved in the transport of various organelles. The Rab27 subfamily is very similar to the Rab3 subfamily, and the Rab27 isoforms Rab27A and Rab27B are expressed in humans and the mouse. A mutation of the Rab27A gene causes a hereditary disease in humans, called Griscelli syndrome which is manifested by pigment anomalies and impaired immunity. Activated GTP-Rab27A is involved in the melanosome transport and the release of a variety of secretory granules, by binding to a specific effector molecule (e.g., synaptotagmin-like protein (Slp), Slac2). Rab27B, as well as Rab27A, is expressed on the surface of secretory granules and is known to be involved in amylase secretion by the parotid gland. For research use only, not for use in diagnostic procedures.
- application:
- WB
- Catalog number:
- 18975-S
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Recombinant Rab27B protein
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Affinity Purified with antigen protein
- size:
- 10 µg
- specificity:
- Cross-react with mouse and rat Rab27A/B. Non-cross-react with the Rab3 subfamily.
- storage:
- Lyophilized product, 5 years at 2 - 8 °C, Solution, 2 years at -20 °C
- Host:
- Rabbit
- Additional info:
- References:
