Apolipoprotein E (ApoE) is a structural component of very low-density lipoprotein (VLDL) synthesized by the liver and intestinally synthesized chylomicrons. It is also a constituent of a subclass of high-density lipoproteins (HDLs) involved in cholesterol transport activity among cells. One of the most important roles of ApoE is to mediate high affinity binding of chylomicrons and VLDL particles that contain ApoE to the low-density lipoprotein (LDL) receptor. This allows for the specific uptake of these particles by the liver that is necessary for transport preventing the accumulation in plasma of cholesterol rich remnants. There are indications that ApoE is also involved in immune system regulation, nerve regeneration and muscle. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB
- Catalog number:
- 18171
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide for C-terminal of Human ApoE
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Apolipoprotein-E
- Protocol:
- purification:
- Affinity Purified with antigen peptide
- size:
- 100 µg
- specificity:
- Reacts with ApoE2, ApoE3 and ApoE4
- storage:
- Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
- Species:
- Human
- Host:
- Rabbit
