Skip to main content

Infliximab (Remicade®, Remsima®, and Inflectra®) ELISA

$1,110.00
SKU:
TM09001
Bulk Pricing:
Buy in bulk and save
Adding to cart… The item has been added

Immunoguide® Enzyme immunoassay (ELISA) for the determination of free Infliximab in serum and plasma.<br><br>

The drug Infliximab (trade name Remicade®, Remsima®, Inflectra®) is a chimeric monoclonal antibody and used to treat auto-immune disorders. It reduces the amount of active tumor necrosis factor alpha (hTNFα) by binding to it and preventing it from signaling the receptors for TNFα on the surface of various cell types. TNFα is one of the key cytokines that triggers and sustains the inflammatory reactions. The drug is used for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, ulcerative colitis.<br><br>

Single intravenous (IV) infusion of 3 mg/kg to 20 mg/kg showed a linear relationship between the dose administered and the maximum serum concentration. The volume of distribution at steady state was independent of dose and indicated that Infliximab was distributed primarily within the vascular compartment.<br><br>

Identification of biomarkers for (non-)response and risk factors for adverse drug reactions that might be related to serum concentrations and maintaining the effective concentration of Infliximab in order to potentially avoid some side effects with a reliable method might be beneficial. For research use only, not for use in diagnostic procedures.

Assay Description:
60 min. incubation (RT) + 30 min. (RT) + 15 min. (RT) = 1 hour, 45 min. total incubation time
Catalog number:
TM09001
configuration:
96 Determinations, 12x8 removable strips
controls:
None provided
design:
Enzyme immunoassay (ELISA) technique
FDA Status:
For research use only, not for use in diagnostic procedures
MSDS:
Available upon request
notes:
The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
Protocol:

Protocol

Sample types:
Serum and plasma
Sample volume:
10 µL
standards:
5 standards, ready to use
Standard range:
0 / 6 - 200 ng/mL
storage:
2 - 8 °C
sensitivity:
5 ng/mL
Species:
Human
Products related:
Infliximab (mAb-based) ELISA
Anti-Infliximab (ATI) ELISA
Additional info:

Pamphlet