ImmunoGuide® Enzyme immunoassay (ELISA) test kit for the determination of free antibodies to Bevacizumab in serum and plasma.<br><br>
The drug Bevacizumab (trade name Avastin®) is a recombinant human IgG1:monoclonal antibody specific for all human vascular endothelial growth factor-A (VEGF-A) isoforms and it has been approved by the FDA as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy. Furthermore, VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration. As with all therapeutic proteins, there is a potential for immunogenicity. According to the manufacturer’s product insert; the incidence of antibody development in patients receiving Bevacizumab has not been adequately determined because the assay sensitivity was inadequate to reliably detect lower titers.<br><br>
The ImmunoGuide Antibody to Bevacizumab ELISA Kit can be used for monitoring anti-Bevacizumab antibodies during therapy and offers the clinician a tool for decision on possible preventive measures. For research use only, not for use in diagnostic procedures.
- Assay Description:
- 1 hour incubation (RT) + 1 hour (RT) + 15 min. (RT) = 2 hours, 15 min. total incubation time
- Catalog number:
- TM09012
- configuration:
- 96 Determinations, 12x8 removable strips
- controls:
- Positive control
- design:
- Enzyme immunoassay (ELISA) technique
- FDA Status:
- For research use only, not for use in diagnostic procedures
- MSDS:
- Available upon request
- notes:
- The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
- Protocol:
- Sample types:
- Serum and plasma
- Sample volume:
- 10 µL
- Standards:
- 5 Standards, ready to use
- Standard range:
- 0 / 30 - 1000 ng/mL
- storage:
- 2 - 8 °C
- sensitivity:
- 40 ng/mL
- Species:
- Human
- Products related:
- Bevacizumab (Avastin®) ELISA
Bevacizumab (Avastin®) (mAb-based) ELISA - Additional info:
