Angiopoietin-like proteins (ANGPTLs)
Oct 19th 2020
Angiopoietin-like proteins (ANGPTLs) are secretory form proteins which are similar in structure to angiopoietin which is an angiogenesis factor. 7 ANGPTLs have been identified.
ANGPTL2 has been found to affect vascular cells and monocytes, and it has also been known that ANGPTL3 and ANGPTL4 play important roles in lipid metabolism.
AGF (Angiopoietin-like growth factor)/ ANGPTL6 contributes in energy metabolism.
These various biological effects of ANGPTL family are attracting attention as a new target of strategy against lifestyle-related diseases like metabolic syndrome or cancer.
There is a report that high level of ANGPTL2 in blood observed in individuals who suffer obesity, strong insulin resistance, diabetes and arteriosclerosis.