New ELISA Angiotensinogen assay offerings

Aug 25th 2020

IBL-America is pleased to announce the release of new ELISA kits for measuring Angiotensinogen in Mouse and Rat.

IBL-America now offers a comprehensive, reliable angiotensinogen assay portfolio to support research in Human, Mouse and Rat samples.

Total AGT

27412Human Total AGT
27103 MouseTotal AGT New!
27104 RatTotal AGT New!

Intact AGT
27742 HumanIntact AGT
27105 MouseIntact AGT New!
27106 RatIntact AGT New!

For research use only and not for use in diagnostic procedures.

Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system. It has long been shown to play an important role in controlling blood pressure.

Recent studies have investigated angiotensinogen as a potential marker for identifying subjects at risk for chronic kidney disease. Also in recent years, interest related to the role of the renin-angiotensin system in arterial pressure control and the pathophysiology of hypertension has been shifting to its local role in various tissues.

Among the studies urinary excretion of angiotensinogen in a rat model of angiotensin II (AII)-dependent hypertension was reported to be a marker of the activity of the local intrarenal renin-angiotensin system.

Intrarenal AII increases to an extent in AII-dependent hypertension that cannot be explained by the plasma AII equilibration alone, and two mechanisms, an increase in intracellular uptake of AII and an increase in intrarenal expression of angiotensinogen, have been proposed to explain it.