Newly Released! 27267 Human GPIHBP1 Autoantibody Assay Kit

GPIHBP1 (Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1) is an anchor protein that is modified by glycolipids.  It has been known to exist on capillary endothelial cell membranes and is involved with metabolism of triglyceride rich (TG-rich) lipoproteins (triglyceride). 

GPIHBP1 transports lipoprotein lipase (LPL) synthesized and secreted in adipocyte or skeletal muscle cells into capillary lumen by transcytosis and it binds LPL on the surface of endothelial cells so that GPIHBP1 has a critical role in metabolizing TG-rich lipoprotein. 

It has been recognized that type I hyperlipemia (hyperchylomicronemia) can be caused by GPIHBP1 gene mutation, however, the new insight regarding existence of GPIHBPI autoantibody as a novel pathological unit has been reported in the following paper published in the New England Journal of Medicine (NEJM).

A Woman With HypertriglyceridemiaWho Acquired AntibodyAgainst GPIHBP1 Hirano et al. JACC: CASE REPORTS
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. Beigneux AP et al. N Engl J Med. 2017 Apr 27;376(17):1647-1658.

The kit is an indirect ELISA for the determination of human GPIHBP1 Autoantibody in serum, EDTA-plasma, heparin plasma, and post-heparin EDTA-plasma. 

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