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Capone R, Tiwari A, Hadziselimovic A, Peskova Y, Hutchison JM, Sanders CR, Kenworthy AK. The C99 domain of the amyloid precursor protein resides in the disordered membrane phase. J Biol Chem. 2021 Jan … read more

Amyloid-beta is generated through amyloid precursor protein (APP) cleavage by specific secretases. Beta-secretase cleaves an extracellular portion of APP and frees a soluble peptide. Gamma-secr … read more