Serine/threonine-protein kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumor diagnosis and prognosis.
The BRAF V600E (IHC600-1) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods.
- application:
- IHC
- Catalog number:
- IHC600-1
- clone:
- IHC600
- concentration:
- N/A
- Datasheet:
- formulation:
- Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
- immunogen:
- BRAF Peptide
- isotype:
- IgM
- MSDS:
- N/A
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- N/A
- Protocol:
- N/A
- size:
- 1.0 mL
- storage:
- 2-8°C (Do not freeze).
- Species:
- Human
- Host:
- Mouse