Erc has been identified as a gene showing stronger expression in cancer-affected renal cell than in normal renal tissue in Eker rats (a rat model of renal cancer). The human homologue of the protein encoded by this gene is called MPF (megakaryocyte potentiating factor) or mesothelin. This protein is detected especially prominently in mesothelial cells, and its involvement has been suggested in the development of mesothelioma, making it a promising tumor marker. In humans, involvement of this protein has also been suggested in the development of pancreatic, ovarian and pulmonary cancers, etc. The protein is expressed as a GPI anchor-type membranous protein (about 71 kDa in molecular weight), which is thought to be digested by a furin-like protease to yield fragments about 31 kDa and 40 kDa in size. We have prepared an antibody specific to C-ERC/Mesothelin (40 kDa fragment). For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB, FCM
- Catalog number:
- 10357
- clone:
- 22A31
- concentration:
- 1.0 mL deionized water will be added to the product, then its concentration comes to 100 µg/mL
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Recombinant protein for Human C-ERC/Mesothelin
- isotype:
- IgG
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Protocol:
- size:
- 100 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Mouse
- References:
