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CD109 (11H3) Anti-Human Mouse IgG MoAb

$550.00
SKU:
10381
Bulk Pricing:
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CD109 is a glycosyl-phosphatidyl-inositol (GPI) - anchored glycoprotein about 180 - 190 kDa. It is shown that CD109 is expressed in vascular endothelial cells, some epithelial cells, activated T-cells and platelets, and subset of CD34+ megakaryocytic leukemia cells. The CD109 molecules are strongly expressed in KG1a cells, while CD34+CD109+ cells in fetal bone marrow include almost all myelocytic, erythroblastec and megakaryocytic precursor cells. For this reason, CD109 is considered to be a marker of megakaryocytic hematopoiesis in early stage. And CD109 is considered different from existing activation marker of leukocyte and platelet because of its structure and serological features. By reports of Takahashi et al., CD109 is significantly over expressed in squamous cell carcinoma such as lung carcinoma, esophageal carcinoma and uterine cervical carcinoma. Thus, it is attracting attention in study of squamous cell carcinoma. Additionally, a recent study suggests that CD109 is involved in the regulation of transforming growth factor (TGF)-β signaling in some cancer cells and keratinocytes. For research use only, not for use in diagnostic procedures.

application:
WB, IP, IHC
Catalog number:
10381
clone:
11H3
Datasheet:

Click for Datasheet

formulation:
Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
immunogen:
Recombinant protein of the C-terminal portion of Human CD109
isotype:
IgG1
MSDS:

Click for MSDS

notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Protocol:

Click for Antibody Protocol

size:
100 µg
storage:
Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
Species:
Human
Host:
Mouse