Parkinson's Disease (PD) is a relatively common neurodegenerative disorder, which is characterized by the loss of midbrain dopamine (DA) neurons and the presence of Lewy bodies, proteinaceous cytoplasmic inclusions that are abundantly enriched in ubiquitin. It is identified a number of potential substrates for parkin, which may be involved in the pathogenesis of PD. One of parkin's potential substrates is CDCrel-1. Mutations in parkin impair its ability to regulate the turnover of CDCrel-1. CDCrel-1 belongs to a family of septin GTPases and may regulate synaptic vesicle release in the nervous system. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB, ICC
- Catalog number:
- 18921-S
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide of part of C terminal of human CDCrel-1 (RMQEMLQRMKQQMQDQ)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 10 µg
- specificity:
- Cross-reacts with Mouse and Rat
- storage:
- Lyophilized product, 5 years at 2 - 8 °C, Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Rabbit
