Enzyme immunoassay for determination of Corticosteroid-binding Globulin (CBG) (SERPINA6) concentrations in serum, plasma,
cell culture supernatant and other biological samples.
For research use only. Not for use in diagnostic procedures.
SerpinA6, also known as CBG (Corticosterone-Binding Globulin) or Transcortin, is a 405 amino acid α-globulin secreted protein that belongs to the serpin family. Synthesized in the liver and present in glycocorticoid responsive cells, SerpinA6 functions as the primary transport protein for progestins and glucorticoids within the blood. Additionally, SerpinA6 has corticosteroid-binding properties through which it can regulate the physiological binding of serum cortisol within the cell. Defects in the gene encoding SerpinA6 are the cause of corticosteroid-binding globulin deficiency (CBG deficiency), a rare disorder characterized by reduced corticosteroid-binding rates that result in hypo/hypertension and muscle fatigue.