COX-1 and COX-2 (Cyclooxygenase 1,2) are also called prostaglandin endoperoxide H synthase, and are important enzymes as catalysts for the reaction in prostaglandin H2 (PGH2) synthesis from the arachidonic acid. COX-1 and COX-2 have the homology of about 60% at the amino acid level. COX-1 is expressed constitutively in many organs such as kidney, stomach, vascular smooth muscle or platelets widely and it is thought to play a so-called housekeeping role. On the other hand, COX-2 cannot be usually detected from organs, however, it is high-level expressed by macrophage and other cells in response to the stimulation such as various cytokines, hormones, the tumor cause medicines, inflammation mediators, or mitogens, therefore, it is thought that COX-2 produces prostaglandin in relation to the inflammation condition. For research use only, not for use in diagnostic procedures.
- application:
- WB, IHC
- Catalog number:
- 18521
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide for a part of Rat COX-1
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Affinity Purified with synthetic peptide
- size:
- 100 µg
- specificity:
- Rat COX-1 specific. Non-cross-reacts with Human COX-1 and Rat COX-2
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Rat
- Host:
- Rabbit
