Classical (β-catenin dependent) and non-classical (β-catenin non-dependent) Wnt signal pathway are signal pathways that regulate forming and maintaining of embryonic growth or cell structures of organs and amplifying of cells. It is also involved in various diseases including cancers. Especially, it has been well known that the non-classical Wnt signal pathway regulates polarity determination of tissues and migration of cells. It has been revealed that scaffold molecule “Dishevelled (Dvl)” and low molecular weight GTPase “Rho molecular group (Rac, Rho)” that activates downstream have essential roles in this pathway.<br><br>
Daple is a molecule that was identified by A. Kikuchi et al, Osaka University and it shows that it has a homological sequence with Girdin or Gipie. It is suggested that Daple binds to Dvl and controls activation of Rac depended on Wnt5a stimulus via its mutual interaction. It was discovered that Daple is essential for cell migration and restructuring of actin structure and its molecular mechanism has also an important role for healing of wound of skin by Daple knockout mouse analysis. For research use only, not for use in diagnostic procedures.
- application:
- IHC, ICC, WB
- Catalog number:
- 28147
- Datasheet:
- formulation:
- Lyophilized product in PBS containing 1% BSA and 0.05% NaN3
- immunogen:
- Synthetic peptide of Daple (EPGGDPQTVWYEYG)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Protocol:
- purification:
- Affinity purified with antigen peptide
- size:
- 100 µg
- specificity:
- Cross-react with Human Daple
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
- Additional info:
