Fibroblast Growth Factor 19 (FGF19)

Solid phase sandwich ELISA for the determination of human FGF19 in EDTA plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures.<br><br>

FGF19 subfamily composed of FGF19, FGF21 and FGF23 binds the receptors, α/βKlotho and it is characterized as a factor group which has hormonal functions. The novel system consisted of α/βKlotho and FGF19 subfamily regulates integrally metabolism of minerals, lipids, energy and amino acids. This novel regulating system involves important homeostatic mechanism for biological body such as metabolism of bile acid and cholesterol in the liver (FGF19), energy and glycolipids metabolism (FGF21) and phosphate, calcium and vitamin D metabolism in kidney (FGF23) in fasting state. FGF19 is secreted from intestine and transported to liver through bloodstream. It suppresses synthesis of bile acid in liver and regulates the function of liver that preserves sugar as a glycogen. FGF19 binds a receptor consisted of FGFR4 and βKlotho. FGF19 is studied in relation to digestive disorders such as diarrhea and constipation which might be related to FGF19 hormonal abnormality and metabolic disorders such as diabetes. The concentration of FGF19 in blood is measured and reported its involvement with many disease such as polycystic ovary syndrome history, bile acid diarrhea, coronary artery disease, pediatric nonalcoholic fatty liver disease, impaired fasting glucose, quiescent Crohn's colitis, hepatocellular carcinoma, type 2 diabetic patients with metabolic syndrome and anorexia nervosa. This kit can assay Human blood FGF19 density.