Gastrin is one of the most important gut-related hormones contributing to gastric acid secretion. Gastrin and the gastrin receptor (GR) are co-expressed in many gastrointestinal cancer cell lines, and gastrin is regarded as an autocrine growth factor for these cells. Thus, gastrin is important in the investigation of gastrointestinal carcinogenesis and anticancer therapy. The GR (identical with the cholecystokinin B receptor; CCKBR ) gene was cloned by Lee et al. and has an open reading frame encoding 447 amino acids with 7 transmembrane domains. To date, many studies have revealed the localization of GR in the human stomach. It has been of public interest to investigate the expression and potential role of gastrin and GR in gastric carcinogenesis and their relation to Helicobacter pylori infection and inflammation. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB
- Catalog number:
- 28103
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide of the C-terminal part of Human Gastrin Receptor (CTPSIASLSRLSYTTIS)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Protocol:
- purification:
- Purified with antigen peptide
- size:
- 100 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
