Glucagon-like Peptide-1 (GLP-1), Active Form (High Sensitivity)

Solid phase sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of GLP-1 (Active Form) in human, mouse and rat EDTA-plasma, and cell culture supernatant. For research use only, not for use in diagnostic procedures. <br> <br>

GLP-1 (Glucagon Like Peptide-1) is a transcriptional product of proglucagon gene as same as glucagon and one of gastrointestinal hormone which is secreted from L cells of lower section of the small intestine. GLP-1 (7-36) amide and GLP-1 (7-37) are active form and these peptides are dissolved in blood by DDP4 (dipeptidyl peptidase-4) into GLP-1 (9-36) amide and GLP-1 (9-37) and these peptides lose its activities in short period. GLP-1 is known as incretin as same as GIP (Glucose-dependent Insulinotropic Polypeptide), it promotes secretion of insulin from β cells of the isles of Langerhans in the pancreas as glucose dependently. GLP-1 also suppresses secretion of glucagon from α cell of pancreas and concentration of glucose in blood after meal. Drug of type 2 diabetes has been developed by utilizing the functional mechanism of GLP-1 such as blood sugar control through pancreas, delayed gastric emptying and appetite suppression which contributes weight loss as extra-pancreatic effects. This ELISA kit can quantitatively and specifically measure GLP-1, active form (GLP-1(7-36) amide and GLP-1 (7-37)).<br><br>