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Infliximab (Remicade®, Remsima®, and Inflectra®) (mAb-based)

$1,110.00
SKU:
TM09002
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ImmunoGuide® Enzyme immunoassay (ELISA) test kit for the determination of free Infliximab (Remicade®, Remsima®, and Inflectra®) in serum and plasma.<br><br>

The drug Infliximab (trade names Remicade®, Remsima®, and Inflectra®) is a chimeric monoclonal antibody and used to treat auto-immune disorders. Infliximab reduces the amount of active human tumor necrosis factor alpha (hTNF-α) in the patient by binding to it and preventing it from signaling the receptors for TNF-α on the surface of various cell types. TNF-α is one of the key cytokines that triggers and sustains the inflammatory reactions. Infliximab is used for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, ulcerative colitis. The specificity of this test system is achieved by using a monoclonal antibody named "Peri-1 mAb" for the coating of the microtiter plate. This antibody is specific for Infliximab only (regardless whether Remicade®, Remsima®, or Inflectra®) and does not cross react with other TNF-α catchers.<br><br>

In this context, identification of biomarkers for (non-)response and risk factors for adverse drug reactions relating to serum concentrations and therapeutic drug monitoring of Infliximab would be very helpful.  The catcher is a highly specific mAb and the detection antibody is a HRP-labeled mAb binding at the Fc part of the drug. This assay design makes sure that there is no cross reactivity with any other TNF-α catcher. For research use only, not for use in diagnostic procedures.

Assay Description:
60 min. incubation (RT) + 30 min. (RT) + 10 min. (RT) = 1 hour, 40 min. total incubation time
Catalog number:
TM09002
configuration:
96 Determinations, 12x8 removable strips
controls:
None provided
design:
Enzyme immunoassay (ELISA) technique
FDA Status:
For research use only, not for use in diagnostic procedures
MSDS:
Available upon request
notes:
The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
Protocol:

Protocol

Sample types:
Serum and plasma
Sample volume:
10 µL
standards:
5 standards, ready to use
Standard range:
0 / 5 - 150 ng/mL
storage:
2 - 8 °C
sensitivity:
3 ng/mL
Species:
Human
Products related:
Infliximab ELISA
Anti-Infliximab (Remicade®) (ATI) ELISA
Additional info:

Pamphlet