Leptin (Highly Sensitive)

Solid phase sandwich ELISA for the determination of Human Leptin in serum, EDTA-plasma and supernatant of cell culture media. For research use only, not for use in diagnostic procedures.<br> <br>

This is an improved kit of current product #27172, Human Leptin Assay Kit - IBL. The leptin concentration in human serum and EDTA plasma can be assayed with high sensitivity including normal range by using this improved kit. Please note that the current product #27172, Human Leptin Assay Kit - IBL will be discontinued as of end May 2009 by releasing this improved kit. The recessive obesity mutation, ob, identified in 1950, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. Freidman’s group at Rockefeller University originally identified the obesity gene that encodes for Leptin in 1994. Leptin is a 16 kDa secreted protein produced by the ob gene. Adipose tissue produces Leptin and releases it into the bloodstream. As fat deposits grow, blood Leptin levels tend to increase. It has been suggested that Leptin acts as a lipostat, increasing as fat gets deposited into adipocytes. It is also found that the protein acts as a hormone instructing the brain to stop food consumption and to increase activity. The protein has also been shown to signal and probably control the onset of puberty. In addition, recent study shows Leptin acts as a potent inhibitor of bone formation through central nervous system. This ELISA kit has a high sensitivity for measuring Human Leptin.