The p53 tumor suppressor protein is stabilized in response to cellular stress, resulting in activation of genes responsible for either cell cycle arrest or apoptosis. The cellular pathway for releasing normal cells from p53- dependent cell cycle arrest involves the MDM2 protein. Recently, a p53- binding protein with homology to MDM2 was identified and called MDMX. Like MDM2, MDMX is able to bind p53 and inhibit p53 transactivation. It is proposed that the MDMX protein may function to maintain a nuclear pool of p53 protein in undamaged cells. For research use only, not for use in diagnostic procedures.
- application:
- WB
- Catalog number:
- 10201
- clone:
- 77A1
- concentration:
- Please see datasheet
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Human MDMX Recombinant protein
- isotype:
- IgG1
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- size:
- 100 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Mouse
