mLST8 (mammalian lethal with sec-13), an about 39 kDa protein which has WD40 domains, has been identified as a configuration factor of mTORC1/mTOR complex 1 and then found to be also a configuration factor of mTORC2. mLST8 is conserved over species and widely expressed in a variety of cells. It is assumed that mLST8 plays a role in promoting activity of mTOR kinase, for mLST8 binds to the kinase domain of mTOR and phosphorylation of p70 S6 (a substrate of mTOR kinase) decreases by RNAi. For research use only, not for use in diagnostic procedures.
- application:
- WB, IP
- Catalog number:
- 28013
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide of N-terminal of Human mLST8 (TAGYDHTVRFWQAHSGIC)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 100 µg
- specificity:
- Please see datasheet
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
