Monoclonal Antibodies

Monoclonal antibodies (mAb or moAb) are derived from a single B-cell parent clone and therefore only recognize a single epitope per antigen.

These B-cells are immortalized by fusion with hybridoma cells, allowing for long-term generation of identical monoclonal antibodies.

Monoclonal antibodies specifically detect a particular epitope on the antigen and therefore are less likely than polyclonal antibodies to cross-react with other proteins.

IBL-America offers a wide range of monoclonal antibodies that can be used in the research and development of multiple laboratory testing applications.

Tie-1 (9C1) Anti-Human Mouse IgG MoAb 1

TIE is a new receptor-type tyrosine kinase that was cloned from K562, a chronic myelocytic leukemia cell line. Its molecular weight is 117 kDa and its structure begins with an immunoglobulin-like domain from the extracellular N terminal, continues to 3...

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PDGFRβ (22B1) Anti-Human Mouse IgG MoAb 1

PDGF, a ligand of PDGFR, has 4 isofoms, A-, B-, C- and D-chains, and forms hetero and/or homo dimers, PDGF-AA, -AB, -BB, -CC, -DD. On the other hand, PDGFR has 2 isoforms, α- and β-chains and forms hetero and/or homo dimers,...

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KDR (23B31) Anti-Human Mouse IgG MoAb 1

KDR, alternative name Flk-1 (type 2 receptor), is one of the receptors for VEGFs, important growth factors for vasculogenesis, angiogenesis and lymphangiogenesis. Flt-1 (type 1 receptor) is also known as a VEGF receptor. In particular, it is believed...

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CD20 (N) (4-6H:2C) Anti-Human Mouse IgG MoAb 1

Rituximab used for treatment of lymphoma is an antibody drug of which target is pan-B cell marker, CD20. It has been reported that the C-terminal region of CD20 undertakes a critical role in a binding to rituximab and the association between C-terminal...

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BEC12 (LA5) Anti-Mouse Mouse IgG MoAb 1

Recent years, specific antigens of vascular endothelium have been found one after another, and they contribute to progress of vascular biology. This antibody, being unlike any other prior antibodies, reacts especially with arterial microcirculating...

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LEC26 (LA102) Anti-Mouse Rat IgG MoAb 1

Recent years, LYVE-1 (1999, Banerji et al.), podoplanin (1999, Breiteneder-Geleff et al.) and Prox-1 (1999, Wifle & Oliver) were found one after another as specific antigens of lymphatic endothelium and the approach to lymphatic study has progressed...

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Angiotensinogen (104AT 601.2.80) Anti-Human Mouse IgG MoAb 1

Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role...

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VEGF (R11) Anti-Human Mouse IgG MoAb 1

Vascular Endothelial Cell Growth Factor (VEGF) is a homodimeric protein initially purified from media conditioned by normal bovine pituitary folliculo-stellate cells and secreted by a variety of vascularized tissues. It was subsequently found to be...

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Anti-DPD (ADPYDMAB) Mouse IgG MoAb 1

Thymidylate synthase/TS (EC 2.1.1.45), Dihydropyrimidine degydrogenase/DPD (EC 1.3.1.2), Thymidene phosphorylase/TP (EC 2.4.2.4) and Orate phosphorybosyl transferase/OPRT (EC 2.4.2.10) are known as key enzymes related to nucleic-acid metabolism within...

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Anti-TS (ATYMSMAB) Mouse IgG MoAb 1

Thymidylate synthase/TS (EC 2.1.1.45), Dihydropyrimidine degydrogenase/DPD (EC 1.3.1.2), Thymidene phosphorylase/TP (EC 2.4.2.4) and Orate phosphorybosyl transferase/OPRT (EC 2.4.2.10) are known as key enzymes related to nucleic-acid metabolism within...

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Anti-Poly (ADP-ribose) (10H) Mouse IgG MoAb 1

The poly ADP-ribosylation is one of post translational modification of proteins, and is the addition of many ADP-ribose moieties to a protein. This protein modification is carried out by the poly ADP-ribose polymerases (PARPs), which are found in most...

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Niban (110C4) Anti-Human Mouse IgG MoAb 1

Niban has been cloned from cell lines derived from Eker rat by AFLP-Differential Display method as a novel gene which is increased in the early stage of renal carcinogenesis. Then, it has been reported that Niban protein is expressed in various cancer...

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