Cadherins are a family of Ca2+-dependent intercellular adhesion molecules. They play an important role in cell-cell interaction, histogenesis and cellular transformation, and association with the actin cytoskeleton regulates their function by a complex of cytoplasmic proteins called the catenins (α, β, γ). Among the cadherin protein family, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of β-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events. For research use only, not for use in diagnostic procedures.
- application:
- Please see datasheet
- Catalog number:
- 18571-S
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05 % NaN3
- immunogen:
- Recombinant human N-Cadherin extracellular subdomain 1-3
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Affinity purified with antigens
- size:
- 10 µg
- specificity:
- Non-cross reacts with another cadherin’s transfectants
- storage:
- Lyophilized product, 5 years at 2 - 8 °C, Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Rabbit
