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Angiotensinogen (Total)
Angiotensinogen. Solid phase sandwich ELISA for the determination of human Total Angiotensinogen in serum, EDTA-plasma, urine, or cell culture media. For research use only, not for use in diagnostic procedures.<br><br> Angiotensinogen is the...
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Human soluble Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of human soluble Alpha Klotho (α-Klotho) in serum and EDTA-plasma. For research use only, not for use in diagnostic procedures.<br><br> α-Klotho is a key player that integrates a...
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Gd-IgA1 (Galactose-deficient IgA1)
Solid phase sandwich ELISA for the determination of Gd-IgA1 (Galactose-deficient IgA1) in human serum, EDTA-plasma, and urine. For research use only, not for use in diagnostic procedures.<br><br> Galactose-deficient IgA1 (Gd-IgA1) attracts a...
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Gd-IgA1 (KM55) Anti-Human Rat IgG MoAb
Galactose-deficient IgA1 (Gd-IgA1) attracts a lot of attentions as a critical effector molecule in the pathogenesis and progression of IgA nephropathy (IgAN) in recent studies. It has been suggested that several O-link glycans modified regions exist in...
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Plasma Renin Activity (PRA) ELISA Kit
Enzyme immunoassay (ELISA) for the determination of Plasma Renin Activity (PRA) in human EDTA plasma. For research use only, not for use in diagnostic procedures.<br><br> Measurement of PRA is important for the research of hypertensive...
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Soluble (Pro)renin Receptor
(Pro)renin receptor/(P)RR is a common receptor protein between renin and prorenin. It has an ability at an equivalent level as renin to bind angiotensinogen and a catalytic activity for conversion from angiotensinogen to angiotensin I once it binds to...
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Aldosterone ELISA
Competitive enzyme-linked immunosorbent assay (ELISA) for the determination of Aldosterone in serum, plasma or urine. For research use only, not for use in diagnostic procedures.
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Angiotensinogen (405) Anti-Mouse/Rat Rabbit IgG Affinity Purify
Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role...
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Human soluble Alpha Klotho (α-Klotho) Control Set
Used as a complementary component for Human soluble Alpha Klotho (α-Klotho), catalog #27998. For research use only, not for use in diagnostic procedures.
Add to Cart$132.00 -
Angiotensinogen (405) Anti-Mouse/Rat Rabbit IgG Affinity Purify 1
Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role...
Add to Cart$132.00 -
Rat Angiotensinogen (Total)
Solid phase sandwich ELISA for the determination of rat Total Angiotensinogen ELISA in serum, EDTA-plasma, urine and cell culture supernatant. For research use only, not for use in diagnostic procedures. <br><br> Angiotensinogen is a...
Add to Cart$827.00 -
Human Angiotensinogen (Intact)
Solid phase sandwich ELISA for the determination of human Intact Angiotensinogen ELISA in serum, EDTA-plasma, and urine. For research use only, not for use in diagnostic procedures.<br><br> Angiotensinogen is the precursor of angiotensin and...
Add to Cart$827.00
Nephrology
Nephrology is the study of the kidney, including both normal kidney function and kidney diseases. The Renin-Angiotensin-Aldosterone System (RAAS), also known as the Renin-Angiotensin System (RAS), is a multi-hormonal system that coordinates a variety of physiological processes for proper regulation of blood volume and pressure. RAAS regulates sodium and water absorption in the kidney, thus directly impacting systemic blood pressure.
Typically, RAAS is activated when a drop in blood pressure (reduced blood volume) occurs to increase water and electrolyte reabsorption in the kidneys, which compensates for the drop in blood volume and increases blood pressure.
When renin is released into the blood, it acts upon a circulating substrate, angiotensinogen, that undergoes proteolytic cleavage to form the decapeptide angiotensin I. Vascular endothelium, particularly in the lungs, has an enzyme, angiotensin converting enzyme (ACE), that cleaves off two amino acids to form the octapeptide, angiotensin II (AII), although many other tissues in the body (heart, brain, vascular) also can form AII.
The one-dimensional standard of kidney disease detection is incompatible with the complexity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Recent advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for studying kidney diseases.
IBL-America offers a variety of unique biomarker assays that may be useful while studying acute kidney injury (AKI) and chronic kidney diseases (CKD).
- Measurement of Galactose-deficient IgA1 (Gd-IgA1) levels may provide information on the pathogenesis of IgA nephropathy (IgAN), a leading renal disease.
- Klotho levels are decreased in AKI and CKD.
- Uromodulin is exclusively produced by the kidneys and is the most abundant protein in normal urine.
- Complement has been shown to have roles in immune-complex glomerulonephritis and the pathogenesis of many non-immune-complex mediated kidney diseases.
Please contact us to learn more about our ELISA offerings available for AKI and CKD research.