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Human Angiotensinogen (Intact) ELISA
Solid phase sandwich ELISA for the determination of human Intact Angiotensinogen ELISA in serum, EDTA-plasma, and urine. For research use only, not for use in diagnostic procedures. Angiotensinogen is the precursor of angiotensin and is cleaved into...
Add to Cart$852.00 -
Aldosterone RIA
Radioimmunoassay for the determination of Aldosterone in human serum and urine. For research use only, not for use in diagnostic procedures.
Choose Options$445.00 -
Osteopontin N-half (Mouse)
Solid phase sandwich ELISA for the determination of Mouse OPN N-Half in EDTA plasma, urine or cell culture media. For research use only, not for use in diagnostic procedures. Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from...
Add to Cart$654.00 -
Angiotensinogen (104AT 601.2.80) Anti-Human Mouse IgG MoAb
Angiotensinogen is the precursor of angiotensin and is cleaved into angiotensin I and II in the renin-angiotensin system, and it has long been reported to play an important role in controlling blood pressure. In recent years interest related to the role...
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Osteopontin (O-17) Anti-Human Rabbit IgG Affinity Purify
Osteopontin (OPN) is a secreted glycoprotein that was originally isolated from bone. Its molecular weights have been reported in the range of 66 kDa to 44 kDa depending on glycosylation and phosphorylation. OPN is also known to be expressed in other...
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Human secreted Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of human secreted Alpha Klotho ( α-Klotho ) in serum, EDTA-plasma, and cerebrospinal fluids (CSF). For research use only, not for use in diagnostic procedures. α-Klotho (Alpha Klotho) was...
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Mouse Intact Angiotensinogen
Solid phase sandwich ELISA for the determination of Intact Angiotensinogen (Full Length Angiotensinogen) in mouse serum and plasma samples. For research use only, not for use in diagnostic procedures. Angiotensinogen is a precursor protein...
Add to Cart$852.00 -
Osteopontin N-half
Solid phase sandwich ELISA for the determination of OPN N-Half in EDTA plasma, urine, synovial fluid or cell culture media. For research use only, not for use in diagnostic procedures. Osteopontin (OPN) is a secretory glycoprotein first isolated...
Add to Cart$654.00 -
Mouse Angiotensinogen (Total)
Solid phase sandwich ELISA for the determination of mouse Total Angiotensinogen ELISA in serum, EDTA-plasma and cell culture supernatant. For research use only, not for use in diagnostic procedures. Angiotensinogen is a precursor protein of...
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ACE2
The Human Angiotensin-converting enzyme 2 (ACE2) ELISA has been designed for the detection of human ACE2 in serum, plasma, tissue homogenates or other biological fluids. For research use only, not for use in diagnostic...
Add to Cart$704.00 -
Mouse soluble Alpha Klotho (α-Klotho) ELISA
Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. α-klotho (Alpha Klotho) was identified as an extremely down-regulated gene...
Add to Cart$852.00 -
Osteopontin (Rat)
Solid phase sandwich ELISA for the determination of Rat Osteopontin (Rat OPN) in plasma (EDTA), urine, or cell culture media. For research use only, not for use in diagnostic procedures. Osteopontin (OPN) is a secreted glycoprotein that was originally...
Add to Cart$654.00
Nephrology
Nephrology is the study of the kidney, including both normal kidney function and kidney diseases. The Renin-Angiotensin-Aldosterone System (RAAS), also known as the Renin-Angiotensin System (RAS), is a multi-hormonal system that coordinates a variety of physiological processes for proper regulation of blood volume and pressure. RAAS regulates sodium and water absorption in the kidney, thus directly impacting systemic blood pressure.
Typically, RAAS is activated when a drop in blood pressure (reduced blood volume) occurs to increase water and electrolyte reabsorption in the kidneys, which compensates for the drop in blood volume and increases blood pressure.
When renin is released into the blood, it acts upon a circulating substrate, angiotensinogen, that undergoes proteolytic cleavage to form the decapeptide angiotensin I. Vascular endothelium, particularly in the lungs, has an enzyme, angiotensin converting enzyme (ACE), that cleaves off two amino acids to form the octapeptide, angiotensin II (AII), although many other tissues in the body (heart, brain, vascular) also can form AII.
The one-dimensional standard of kidney disease detection is incompatible with the complexity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Recent advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for studying kidney diseases.
IBL-America offers a variety of unique biomarker assays that may be useful while studying acute kidney injury (AKI) and chronic kidney diseases (CKD).
- Measurement of Galactose-deficient IgA1 (Gd-IgA1) levels may provide information on the pathogenesis of IgA nephropathy (IgAN), a leading renal disease.
- Klotho levels are decreased in AKI and CKD.
- Uromodulin is exclusively produced by the kidneys and is the most abundant protein in normal urine.
- Complement has been shown to have roles in immune-complex glomerulonephritis and the pathogenesis of many non-immune-complex mediated kidney diseases.
Please contact us to learn more about our ELISA offerings available for AKI and CKD research.