Immunoradiometric assay (IRMA) for the determination of human Neuron Specific Enolase (NSE) in serum. For research use only, not for use in diagnostic procedures.<br><br>
The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase, EC 4.2.1.11) exists as several dimeric isoenzymes (αα, αβ, αγ, ββ and γγ). The γγ and αγ enolase isoenzymes are also known as neuron- specific enolase (NSE) as they are produced in central and peripheral neurons and malignant tumors of neuroectodermal origin.<br><br>
Elevated serum concentrations of NSE are detected in patients with medullar carcinoma of the thyroid, pancreatic islet cell tumor, pheochromocytoma carcinoid, neuroblastoma and small-cell lung carcinoma (SCLC).
- Assay Description:
- 2 hours total incubation time
- Catalog number:
- KIP2471
- configuration:
- Reagents sufficient for 96 determinations
- controls:
- 2 controls, lyophilized
- design:
- Radioimmunoassay (RIA) technique
- FDA Status:
- For research use only, not for use in diagnostic procedures
- MSDS:
- notes:
- The protocol for this product (see above) is intended to serve as an example only. Please refer to the Instructions For Use provided with the assay kit for precise details.
- Other names:
- Neuron Specific Enolase (NSE)
- Protocol:
- Sample types:
- Serum
- Sample volume:
- 50 μL / determination
- standards:
- 6 calibrators, lyophilized
- Standard range:
- 0 / 2.5 - 270 ng/mL
- storage:
- 2 - 8 °C
- sensitivity:
- 0.19 ng/mL
- Species:
- Human
- radioactivity:
- 18.9 µCi (700 kBq)
