Np95 has been originally found as a tumor-specific nuclear antigen of 95kDa in mice. Experiments using B10 strains showed that Np95 is enriched in precancerous cells and is abnormally expressed throughout cell cycle in radiation-induced lymphomatoid cells. Recent attention is put on the epigenetic role of Np95, which mediates the interplay between DNA methylase and hemi-methylated sites to maintain DNA methylation patterns at replication forks. This antibody is available for detection of the human nucleoprotein NP95 (also known as UHRF1), whose function is dependent on S-phase in non-neoplastic cells but could be modified with aberrant cell cycle during tumorigenesis. For research use only, not for use in diagnostic procedures.
- application:
- WB
- Catalog number:
- 10371-S
- clone:
- mt40
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Purified human NP95 protein
- isotype:
- IgG1
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Protocol:
- size:
- 10 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Mouse
