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Parkin (1A1) Anti-Human Mouse IgG MoAb 1

$132.00
SKU:
10241-S
Bulk Pricing:
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Parkinson's Disease (PD) is a relatively common neurodegenerative disorder, which is characterized by the loss of midbrain dopamine (DA) neurons and the presence of Lewy bodies, proteinaceous cytoplasmic inclusions that are abundantly enriched in ubiquitin. It is identified a number of potential substrates for parkin, which may be involved in the pathogenesis of PD. Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson’s Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. For research use only, not for use in diagnostic procedures.

application:
WB, IP, ICC
Catalog number:
10241-S
clone:
1A1
concentration:
Please see datasheet
Datasheet:

Click for Datasheet

formulation:
Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
immunogen:
Synthetic peptide of part of C-terminal of human parkin (AYRVDERAAEQARWEAA)
isotype:
IgG1
MSDS:

Click for MSDS

notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Other names:
Please see datasheet
Protocol:

Click for Antibody Protocol

size:
10 µg
storage:
Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
Species:
Human
Host:
Mouse