Polyclonal Antibodies

Polyclonal antibodies (pAbs) are a combination of antibodies, derived from the immune response of multiple B-cells, and each one recognizes a different epitope on the same antigen.

Polyclonals are produced by injecting an animal with an antigen. This elicits the immune response that produces antibodies against that antigen. The polyclonal immunoglobulins are then purified from the animal’s blood serum.

IBL-America offers a wide range of polyclonal antibodies that can be used in research using multiple laboratory testing methods.

TSC1/Hamartin (T1149) Anti-Human Rabbit IgG Affinity Purify 1

TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin,...

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TPO Anti-Human Rabbit IgG Affinity Purify 1

Thrombopoietin (TPO) is produced primarily in the liver and secondarily in the kidneys and bone marrow. It can bind to a receptor (which is the proto-oncogene c-Mpl, a homolog of an envelope protein of the myeloproliferative leukemia virus) on primitive...

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TNF-α Anti-Rat Rabbit IgG Affinity Purify 1

TNF-α (Tumor Necrosis Factor alpha) is a 17.5 kDa, 157 amino acid protein that is a potent lymphoid factor, which exerts cytotoxic effects on a wide range of tumor cells and other target cells. TNF-α has been suggested to play a...

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Tie (N1125) Anti-Human Rabbit IgG Affinity Purify 1

TIE is a new receptor-type tyrosine kinase that was cloned from K562, a chronic myelocytic leukemia cell line. Its molecular weight is 117 kDa and its structure begins with an immunoglobulin-like domain from the extracellular N terminal, continues to 3...

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α-Synuclein (S122) Anti-Human Rabbit IgG Affinity Purify 1

The pre-synaptic protein, α-synuclein, has been associated with the pathogenesis of several neurodegenerative diseases. These include prevalent conditions such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and the Lewy body variant...

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Syndecan-4 Anti-Human Rabbit IgG Affinity Purify 1

Syndecan, a cell surface proteoglycan, is an integral membrane protein acting as a receptor for the extracellular matrix. The syndecan family of four transmembrane heparan sulfate proteoglycans binds a variety of soluble and insoluble extracellular...

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Anti-Smad3C (Ser 423/425 Phosphorylated) Rabbit IgG Affinity Purify 1

Smads are critical mediators conveying signals from the TGF-β-superfamily members to the nucleus. Activated TGF-β type I receptor (TβRI) and c-Jun N-terminal kinase (JNK) differentially phosphorylate Smad3 to convert two distinctive...

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Sir2/SIRT1 Anti-Human Rabbit IgG Affinity Purify 1

Imai et al. have found that S. cerevisiae Sir2p and its higher eukaryotic orthologs are novel nicotinamide adenine dinucleotide (NAD)-dependent histone/protein deacetylases. Sir2 proteins promote longevity in yeast and in C. elegans by silencing rDNA and...

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Septin 4 (N) Anti-Human Rabbit IgG Affinity Purify 1

A cytoskeletal or scaffold protein family named “septin” has been shown to be involved in diverse phenomena in the living body, including cell division. The term “septin” is derived from “septation,” which means...

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Anti-SCF (K236) Rabbit IgG Affinity Purify 1

Stem cell factor (SCF) and its receptor KIT play an important role in various biologic phases, such as hematopoiesis, reproduction, and regeneration.　 Structurally, c-Kit contains five immunoglobulin-like domains extracellularly and a catalytic domain...

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Anti-SCF (K165) Rabbit IgG Affinity Purify 1

Stem cell factor (SCF) and its receptor KIT play an important role in various biologic phases, such as hematopoiesis, reproduction, and regeneration. Structurally, c-Kit contains five immunoglobulin-like domains extracellularly and a catalytic domain...

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Anti-SCF (K089) Rabbit IgG Affinity Purify 1

Stem cell factor (SCF) and its receptor KIT play an important role in various biologic phases, such as hematopoiesis, reproduction, and regeneration.　 Structurally, c-Kit contains five immunoglobulin-like domains extracellularly and a catalytic domain...

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