RGMa (Repulsive Guidance Molecule a) is a GIP-anchored protein, about 33 kDa, and it is implicated in axonal guidance and neural tube closure of embryonic retina. It has reported as a potent inhibitor of axonal regeneration in the adult central nervous system (CNS). It is speculated that RGMa inhibits neurite outgrowth by activating the RhoA-Rho kinase signaling pathway in vitro. While, it has reported that, in a rat SCI (spinal cord injury) model, neurite outgrowth is enhanced by administration of anti-RGMa antibody to lesion site, resulting they are improved in motor functional recovery. Thus function analysis of RGMa is attracting attention in a research field of axonal regeneration of CNS. This antibody detects human RGMa and can be used for western blotting, immuno-precipitation and FACS analysis. For research use only, not for use in diagnostic procedures.
- application:
- WB, IP, FCM
- Catalog number:
- 10377-S
- clone:
- 410-10
- concentration:
- Please see datasheet
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide of a part of Human RGMa (LYERTRDLPGRAAAGL)
- isotype:
- IgG2b
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- size:
- 10 µg
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Mouse
