RIG-I (retinoic acid inducible gene-I) is one of cytoplasmic viral sencers which has a RNA helicase domain and it is believed to recognize virus-derived double-stranded RNA (dsRNA). It is considered that RIG-I normally exist as inactive form in cytoplasm and turns to active form when it recognizes dsRNA produced as a by-product of viral replication. And it is thought that active form of RIG-I exposes a signaling domain called CARD (caspase recruitment domain) which had been hidden by the steric hindrance and the downstream signaling is activated by interaction of the CARD with IPS-1 expressed on a mitochondria, eventually induces the activation of interferon gene. Thus, RIG-I is believed to play an important role in viral infection-induced signaling. This antibody recognizes CTD (C terminal domain) of RIG-I and is able to detect RIG-I localized in avSGs (antiviral stress granules) that are genesis-induced in virus-infected cells. For research use only, not for use in diagnostic procedures.
- application:
- WB, ICC
- Catalog number:
- 28137
- Datasheet:
- formulation:
- Lyophilized product from PBS containing 1% BSA and 0.05% NaN3
- immunogen:
- Synthetic peptide of CTD domain of human RIG-I (SQEKPKPVPDKENKKLLC)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 50 µg
- specificity:
- Cross-reacts with mouse
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
