The c-MET gene encodes the tyrosine kinase p190MET, the receptor for a molecule known as Scatter Factor (SF) or Hepatocyte Growth Factor (HGF). This molecule has biological activities on epithelial sheets, including mitogenesis, cell-cell dissociation, stimulation of migration into the extracellular matrix, induction of cell polarization and branched tubulogenesis. The p190MET receptor is a heterodimer of two disulfide-linked protein subunits. The RON and SEA genes encode tyrosine kinases that are structurally homologous to the HGF receptor. The three members of MET family elicit the same array of unusual biological responses that include 'scattering', growth, and induction of polarized tubular structures. For research use only, not for use in diagnostic procedures.
- application:
- WB, IP
- Catalog number:
- 18531-S
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Synthetic peptide for a part of C-terminal of human RON
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Affinity Purified with synthetic peptide
- size:
- 10 µg
- specificity:
- Confirmed its specific reaction with RON/BaF3 transfectant
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
