Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by betaand gamma-secretases. A double missense mutation (Lys670→Asn and Met671→Leu) in APP found in a Swedish pedigree (APPβ-sw) elevates Abeta40 and Abeta42 production (1), and the mutation is utilized in establishment of transgenic mice overexpress a mutant form of human amyloid precursor protein (2). Amyloidβproduction and, beta-secretase cleavage of APP β -sw reportedly occur in the endoplasmic reticulum (ER), Golgi and endocytic compartments (3).
- application:
- WB, Immuncytochemistry
- Catalog number:
- 10321
- clone:
- 6A1
- concentration:
- Please see datasheet.
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
- immunogen:
- Synthetic peptide for C-Terminal of Human sAPPβ-sw (ISEVNL)
- isotype:
- IgG3
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Soluble βAmyloid Precursor Protein -Swedish
- Protocol:
- size:
- 100 μg
- storage:
- Lyophilized product, 5 years at 2 €“ 8 „ƒ, Solution, 2 years at €“20 „ƒ
- Species:
- Human
- Host:
- Mouse
- Additional info:
