SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
The SOX-10 (IHC010-1) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed,
paraffin-embedded tissue sections using IHC test methods.
- application:
- IHC
- Catalog number:
- IHC010-1
- clone:
- IHC010
- concentration:
- N/A
- Datasheet:
- formulation:
- Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
- immunogen:
- Recombinant Human SOX-10
- isotype:
- IgG2b
- MSDS:
- N/A
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- N/A
- Protocol:
- N/A
- size:
- 1.0 mL
- storage:
- 2-8°C (Do not freeze).
- Species:
- Human
- Host:
- Mouse
