SP-A (PE10) Anti-Human Mouse IgG MoAb 1

Lung surfactant is a lipoprotein complex which is synthesized and secreted into the alveoli of the lung by type II pneumocytes. Its major protein component, surfactant protein-A (SP-A), is a glycoprotein with a reduced denatured molecular mass of 35 kDa, and is a useful immunohistochemical marker for lung adenocarcinoma. The reactivity of PE10 antibody shows that normal type II pneumocytes and pulmonary macrophages are positive for SP-A in the cytoplasm, whereas type I pneumocytes, bronchial surface epithelial cells and bronchial gland cells are devoid of immunoreactivity. Immunoreactivity for SP-A is also seen in reactive hyperplastic type II pneumocytes, and is stronger in the hyperplastic type II pneumocytes than in normal type II pneumocytes. In primary lung adenocarcinoma, the expression of SP-A is almost the same for the various adenocarcinomas classified by the grade of histological differentiation. For research use only, not for use in diagnostic procedures.