Skip to main content

Tie-1 (9C1) Anti-Human Mouse IgG MoAb 1

$132.00
SKU:
10353-S
Bulk Pricing:
Buy in bulk and save
Adding to cart… The item has been added

TIE is a new receptor-type tyrosine kinase that was cloned from K562, a chronic myelocytic leukemia cell line. Its molecular weight is 117 kDa and its structure begins with an immunoglobulin-like domain from the extracellular N terminal, continues to 3 EGF-like domains, another immunoglobulin-like domain, 3 fibronectin III-like domains, a membrane-penetrating domain, 2 tyrosine kinase domains and a C-terminal domain. It has been reported that Tek molecules with a high homology (about 80%) have been cloned from the kinase domains. These molecules are believed to make up a Tie family. Tie-2 and a receptor type tyrosine kinase Tie-1 that is expressed specifically in endothelial cells are included in this Tie family. Among the Tie-1 gene knockout mice, a vasculature is formed in a homozygote (-/-) but the mouse is likely to succumb to pulmonary edema. Thus it has been reported that the signal via Tie-1 is important in maintaining the vascular structure. For research use only, not for use in diagnostic procedures.

application:
WB, IP, FCM
Catalog number:
10353-S
clone:
9C1
Datasheet:

Click for Datasheet

formulation:
Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
immunogen:
Recombinant protein of extracellular domain of human Tie-1
isotype:
IgG2a
MSDS:

Click for MSDS

notes:
For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details.
Protocol:

Click for Antibody Protocol

size:
10 µg
storage:
Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C
Species:
Human
Host:
Mouse