TIE is a new receptor-type tyrosine kinase that was cloned from K562, a chronic myelocytic leukemia cell line. Its molecular weight is 117 kDa and its structure begins with an immunoglobulin-like domain from the extracellular N terminal, continues to 3 EGF-like domains, another immunoglobulin-like domain, 3 fibronectin III-like domains, a membrane-penetrating domain, 2 tyrosine kinase domains and a C-terminal domain. It has been reported that Tek molecules with a high homology (about 80%) have been cloned from the kinase domains. These molecules are believed to make up a Tie family. Tie-2 and a receptor type tyrosine kinase Tie-1 that is expressed specifically in endothelial cells are included in this Tie family. Among the Tie-1 gene knockout mice, a vasculature is formed in a homozygote (-/-) but the mouse is likely to succumb to pulmonary edema. Thus it has been reported that the signal via Tie-1 is important in maintaining the vascular structure. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB
- Catalog number:
- 18541
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- Part of synthetic peptide of Human Tie-1
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 100 µg
- specificity:
- Confirmed by Tie/BaF3 Transfectant and HEL
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
