Tissue inhibitor of Metalloprotinase 1 (TIMP-1) is endogenous-specific inhibitor produced simultaneously with matrix metalloproteinase (MMP). TIMP-1 inhibits both active MMP to control degeneration of extracellular matrix (ECM) and conversion of intermediate form into active form. In addition, TIMP-1 forms complex with not only active MMP but also potential MMP. Especially, TIMP-1 binds to potential MMP-9 by affinity of C-terminal domain to one another. The degeneration of extracellular matrix is essential step in invasion and metastasis of tumor cell. It is considered that tumor cell collects protease on the surface of cell and degenerates ECM in invading tissue. For research use only, not for use in diagnostic procedures.
- application:
- WB
- Catalog number:
- 18681
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- The part of Synthetic peptide of TIMP-1 protein (177-188)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 100 µg
- specificity:
- Confirmed by Recombinant TIMP-1
- storage:
- Lyophilized product, 5 years at 2 - 8 °C, Solution, 2 years at -20 °C
- Species:
- Human
- Host:
- Rabbit
