TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa. Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor. TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin, a product of another tumor-suppressor gene TSC2 in cytoplasm. The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway. Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division. For research use only, not for use in diagnostic procedures.
- application:
- IHC, WB
- Catalog number:
- 28017-S
- Datasheet:
- formulation:
- Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
- immunogen:
- The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS)
- MSDS:
- notes:
- For research use only, not for use in diagnostic procedures.
The datasheet for this product (see above) is intended to serve as an example only. Please refer to the datasheet provided with the antibody for precise details. - Other names:
- Please see datasheet
- Protocol:
- purification:
- Purified with antigen peptide
- size:
- 10 µg
- specificity:
- Cross-reacts with mouse
- storage:
- Lyophilized product, 5 years at 2 - 8 °C; Solution, 2 years at -20 °C.
- Species:
- Human
- Host:
- Rabbit
