Vitamin D & Bone Metabolism Assays

Vitamin D is the generic term used to designate Vitamin D2 or ergocalciferol and Vitamin D3 or cholecalciferol. Humans naturally produce Vitamin D3 when the skin is exposed to ultraviolet sun rays. In the liver mainly, Vitamin D3 is metabolized into 25-Hydroxyvitamin D3 (25OH D3) which is the main form of Vitamin D circulating in the body. 25OH D3 is a precursor for other Vitamin D metabolites and has also a limited activity by itself.

The most active derivative is 1,25-hydroxyvitamin D3, produced in the kidney (or placenta) by 1-hydroxylation of 25OH D3. 25OH Vitamin D stimulates the intestinal absorption of both calcium and phosphorus and also bone resorption and mineralization. 25OH Vitamin D might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland) and endocrine gland (parathyroid glands, beta cells). Vitamin D3 and Vitamin D2 are also available by ingestion through food or dietary supplementation.

As Vitamin D2 is metabolized in a similar way to Vitamin D3, both contribute to the overall Vitamin D status of an individual. It is the reason why it is very important to measure both forms of 25OH Vitamin D equally for a correct diagnosis of Vitamin D deficiency, insufficiency or intoxication. Vitamin D deficiency is an important risk factor for rickets, osteomalacia, senile osteoporosis, cancer and pregnancy outcomes. The measurement of both 25OH Vitamin D forms is also required to determine the cause of abnormal serum calcium concentrations in subjects. Vitamin D intoxication has been shown to cause kidney and tissue damages.

1,25(OH)2 Vitamin D Extraction Kit

This extraction kit contains quantities of solvents necessary to run: 5 x 48 tests of 1,25(OH)2 Vitamin D RIA-CT (KIR1929) or 2 x 96 tests of 1,25(OH)2 Vitamin D ELISA (KAR1921)

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25OH Vitamin D2/D3 MoAb, Clone LMBP 7011CB

For Monoclonal Antibodies, a careful selection process of ensures a superior specificity profile. Moreover, state of the art production techniques ensure a constant and renewable source of antibodies and all batches are identical. These monoclonal...

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25OH Vitamin D2/D3 MoAb, Clone LMBP 7012CB

For Monoclonal Antibodies, a careful selection process ensures a superior specificity profile. Moreover, state of the art production techniques ensure a constant and renewable source of antibodies and all batches are identical. These monoclonal...

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25OH Vitamin D2/D3 MoAb, Clone LMBP 7013CB

For Monoclonal Antibodies, a careful selection process ensures a superior specificity profile. Moreover, state of the art production techniques ensure a constant and renewable source of antibodies and all batches are identical. These monoclonal...

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FGF23 (Human Intact FGF23) CLEIA ELISA

FGF23 (Fibroblast Growth Factor 23) is a protein belonging to the fibroblast growth factor family. FGF23 is involved in the regulation of phosphorus metabolism. FGF23 has a molecular weight of approximately 32 kDa. FGF23 is produced in bone cells. In...

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Human secreted Alpha Klotho (α-Klotho) ELISA

Solid phase sandwich ELISA for the determination of human secreted Alpha Klotho ( α-Klotho ) in serum, EDTA-plasma, and cerebrospinal fluids (CSF). For research use only, not for use in diagnostic procedures.<br><br> α-Klotho...

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Human soluble Alpha Klotho (α-Klotho) Control Set

Used as a complementary component for Human soluble Alpha Klotho (α-Klotho), catalog #27998. For research use only, not for use in diagnostic procedures.

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Mouse soluble Alpha Klotho (α-Klotho) ELISA

Solid phase sandwich ELISA for the determination of mouse soluble Alpha Klotho (α-Klotho) in mouse urine. For research use only, not for use in diagnostic procedures. <br><br> α-klotho (Alpha Klotho) was identified as an...

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Total Vitamin D derivative - Amino (NH2)

Over the years IBL-America has built partnerships with suppliers with extensive experience in Vitamin D immunoassay development and Vitamin D chemistry. We can provide all components to develop your own Vitamin D assay. Based on a proprietary Vitamin D...

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Total Vitamin D derivative - Biotin

Over the years IBL-America has built partnerships with suppliers with extensive experience in Vitamin D immunoassay development and Vitamin D chemistry. We can provide all components to develop your own Vitamin D assay. Based on a proprietary Vitamin D...

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Total Vitamin D derivative - BSA

Over the years IBL-America has built partnerships with suppliers with extensive experience in Vitamin D immunoassay development and Vitamin D chemistry. We can provide all components to develop your own Vitamin D assay. Based on a proprietary Vitamin D...

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Total Vitamin D derivative - Carboxylic acid (COOH)

Over the years IBL-America has built partnerships with suppliers with extensive experience in Vitamin D immunoassay development and Vitamin D chemistry. We can provide all components to develop your own Vitamin D assay. Based on a proprietary Vitamin D...

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